Argentina could miss out on the World Cup if they fail to beat or draw against Ecuador on Tuesday night, which means Lionel Messi might be absent in Russia.
The rest of the field in CONMEBOL qualification is exceptionally tight and, realistically, the likes of Alexis Sanchez could still miss out on a place at the 2018 World Cup.
Aside from Argentina’s game, Chile travel to Brazil, Paraguay host Venezuela, Bolivia visit Uruguay and Peru take on Colombia.
Join Sportsmail’s Tom Farmery for all of the action from 11.30pm.
For users viewing this on the app, click here for live blog access on the mobile site.
